Viruses are functional biological nanoparticles and also classified as a soft matter system. While viruses majorly related with diseases, they are known to have a crucial role in the genomic evolution as 5-8 % of human genome are comprised of endogenous retroviral genome. The first step of virus infection at cellular level is the attachment of virus nanoparticles to the plasma membrane via specific membrane receptors or attachment factors. This virus-receptor interaction is specific and that is why viruses can infect only specific cell types, typically, called as host cells.

The attachment-detachment kinetics of viruses to the plasma membrane is a complex process and multivalent in nature. Therefore, biomimetic functionalized surfaces are often used as model systems to better understand the fundamentals of virus binding. My research group will utilize different functionalized surfaces for specific binding of viruses and thereafter, scrutinize their binding kinetics and thermodynamics at both ensemble and single particle level. The long-term goal will be to use the functionalized platforms for capturing viruses with greater specificity and their detection at single virus level. The next step of the work will be method development for examining the virus attachment-detachment to their host cells. For this, a novel imaging approach known as expansion microscopy will be established in my group with an aim to achieve super-resolved images of viruses on/in the host cells. Application of the method will provide an enhanced spatial resolution (up to 20 nm) for imaging the interaction between virus and cellular factors in a greater detail.

• Parveen N.*, Rydell G., Larsson G., Hytonen V., Zhdanov V., Hook F.* and Block S.*, “Competition for Membrane Receptors: Norovirus Detachment via Lectin Attachment” J. Am. Chem. Soc. 2019, 141(41), 16303-16311, doi.org/10.1021/jacs.9b06036

• Parveen N., Rimkute I., Block S., Rydell G., Midtvedt D., Larsson G., Hytonen V., Zhdanov V., Lundgren A., and Hook F., “Membrane Deformation Induces Clustering of Norovirus Bound to Glycosphingolipids in a Supported Cell-Membrane Mimic”, J. Phys. Chem. Lett., 2018, 9(9), 2278-2284, DOI: 10.1021/acs.jpclett.8b00433

• Parveen N., Block S., Zhdanov V., Rydell G. and Hook F., “Detachment of Membrane Bound Virions by Competitive Ligand-Binding Induced Receptor Depletion”, Langmuir ACS Editor’s Choice, 2017, 33 (16), 4049-4056 DOI: 10.1021/acs.langmuir.6b04582

• Zetterberg M., Ahlgren S., Hernandez V., Parveen N. and Edwards K., “Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona”, J. Colloid Interface Sci., 2016, 484, 86-96 DOI: jcis.2016.08.067

• Parveen N.*, Jana K. P., and Schoenhoff M.*, “Viscoelastic Properties of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solutions” Polymers, 2019, 11(8), 1285, https://doi.org/10.3390/polym11081285

• Parveen N. and Schoenhoff M., “Swelling and Stability of Polyelectrolyte Multilayers in Ionic Liquid Solution”, Macromolecules, 2013, 6 (19), 7880-7888, DOI: 10.1021/ma401625r

• Assistant Professor, IIT Kanpur, February 2020

• Postdoctoral Researcher, University of Leuven, Belgium, 2017-2019

• Postdoctoral Researcher, Chalmers University of Technology, Sweden, 2014-2017

• Physical Chemistry, Biophysical Chemistry, Spectroscopy, Fluorescence Imaging

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