Early detection of cancer is needed for effective remedial measures. A vast segment of our country’s population does not have easy access to diagnostic centers due to prohibitive costs and location issues, adding to the burden of the disease. Measuring the concentration of disease biomarkers in the body fluids is one diagnostic route. And one path of making healthcare affordable is by developing low-cost portable disease diagnostic units. This project activity is the phase II of an earlier IRHPA funded project to develop a microfluidic based electrolyte-insulator-semiconductor biosensor. Here further answers to specific research questions will be sought and the scientific learning will be utilized to develop an integrated unit.